ABSTRACT
Background: The aim of this study was to assess the relationship between vitamin D level and severity and control of
bronchial asthma among adult Sudanese patients at Alshaab Teaching Hospital.
Methods: This prospective cross-sectional study, conducted at Alshaab Teaching Hospital, Khartoum Sudan in the
period from June to August 2015. Eighty-six asthmatic patients participated in the study after taking their consent.
Demographic data were collected using structured questionnaire, the clinical parameters of asthma severity and
control were measured according to the criteria of Global Strategy for Asthma Management and Prevention 2014 of
the Global Initiative for Asthma (GINA). Airway limitation was assessed using Peak Flow Meter. Three ml of blood
was taken from each patient to measure vitamin D (25(OH)D) using enzyme-linked immunosorbent assay (ELISA)
and data were analyzed using the statistical package for social science (SPSS) version 20.
Results: Normal serum 25(OH)D (30-50ng/ml) was found in only 2.3% of patients. The mean serum 25(OH)D level
in patients with controlled asthma was 25.82±17.27ng/ml while in patients with uncontrolled asthma it
was16.48±7.14ng/ml. (P value = 0.005). The mean serum 25(OH)D level in patients with severe asthma was
16.15±6.9ng/ml (P value = 0.151).
Conclusions: There was a positive correlation between vitamin D level and bronchial asthma control and a negative
correlation with bronchial asthma severity among the study group.
Keywords: Asthma control, Asthma severity, Bronchial asthma, Vitamin D deficiency