Objective Chronic unpredictable stress (CUS) can influence the risk and progression of cancer through increased oxidative stress. Quercetin (QU), a phytochemical found in daily foods, has been extensively studied as a chemopreventive agent against various types of cancers. Our aim was to investigate the role of CUS on the efficacy of QU against DMBA+TPA (7, 12-dimethylbenz (a) anthracene+12-O-Tetradecanoylphorbol-13-acetate)-induced skin carcinogenesis. Methods Eighty-four adult male Swiss albino mice were randomly divided into seven groups (12 mice/group) based on different treatments and killed after 16 weeks. Blood and skin tissues were collected for biochemical estimations, DNA damage...

Abstract: Introduction: The use of stem cell has opened new avenues in the management and cure of diseases in modern era. They have enabled us to achieve remissions and cure in malignancies. They have enormous ability of stimulating the repair process in diseased and damaged tissue. As the medical specialists are a reliable source of information, so their knowledge and approach are vital in counselling the patients regarding the use of stem cells as an advanced treatment option. Aim: To assess the knowledge and attitude level about stem cells and their therapeutic applications among medical undergraduates. Materials and Methods: This cross-sectional study was carried out for a period of six...

Objectives: To understand the perceptions of medical students about the current use of interactive learning, its effectiveness and barriers in its implementation. Method: A cross-sectional study was carried out at the College of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia. Study participants were fifth and final year medical students. A semi-structured questionnaire was used to collect the information in relation to perceptions regarding the use of interactive learning, its effectiveness, and barriers. The questionnaire consisted of Likert scale ranking and close-ended questions. The student’s response was analyzed by frequency analysis. Results: A total of 150...

Objective: To determine the role of ghrelin in stimulating leukopoiesis of myelosuppressed rats by stimulating growth hormone release. Study Design: Randomized controlled trial. Place and Duration of Study: It was conducted at Department of Physiology, Foundation University Medical College, in collaboration with National Institute of Health, Islamabad, from February 2013 to June 2014. Material and Methods: Out of 130 Sprague-Dawley rats, 10 were used for baseline sampling and rest was randomly divided into four groups. Group I received ghrelin only while group II and III were administered intraperitoneally with both carboplatin and 5-flurouracil with and without rat ghrelin. Group IV in...

Background: Ghrelin is a 28-amino acid acylated peptide released from the enteroendocrine cells of stomach. Aim of the study was to find out the possible beneficial role of ghrelin in erythropoiesis of myelosuppressed rats and its possible mediator. Methods: This randomized control trial was carried out at the Department of Physiology Foundation University Medical College in collaboration with the National Institute of Health, Islamabad, from February 2013 to June 2014. A total of 130 Sprague-Dawley rats were randomly divided into four groups. Group I was treated with ghrelin only (1 nmol/100µl), group II received intraperitoneal carboplatin and 5-flurouracil (5-FU) only while group III...

Background: Integration of clinical and preclinical teaching results in improvement of clinical acumen and better understanding of basic medical sciences. Keeping this in view, it was aimed to determine the efficacy of clinical skill lab (CSL) training during preclinical years on acquirement of clinical skills by the medical students. Methods: It was a descriptive study carried out at Foundation University Medical College. Based on convenience sampling, 4th year students who had received CSL training were compared with the 5th year students who had not received CSL training. Evaluation proforma was used. Students graded their clinical skills between non-satisfactory to excellent based upon...

oming to a tertiary care hospital in Islamabad, Pakistan. Study Design: Cross-sectional descriptive study. Place and Duration of Study: The study was conducted in department of Rheumatology at Pakistan Institute of Medical Sciences from Jun 2013 to Dec 2013. Subjects and Methods: A total of 50 patients of PJIA coming to Rheumatology Outpatient Department were recruited in the study after informed consent. Radiographs of cervical spine were performed for each patient in antero-posterior, lateral with flexion and extension and open-mouth views. Radiographs were reviewed for the following features: loss of cervical lordosis, odontoid process erosion, anterior atlantoaxial subluxation, C1-C2...