This course is intended to enhance the comprehension of students regarding the etiological factors and pathogenesis of diseases. The student will learn to apply the knowledge of basic sciences to interpret clinical and morphological changes. The student will understand the mechanisms of disease processes, as manifested by morphologic (gross, microscopic, and ultra-structural) changes in correlation to etiological factors, clinical features and complications of diseases. The student will be able to describe the basic morphologic changes of various disease processes, and formulate differential diagnosis using morphologic appearance. The student will develop concepts and sufficient understanding of the pathologic basis of various disease processes, which would enable him to pursue post-graduate studies, and continuing medical education.