The course focuses on the different metabolic pathways of carbohydrates, proteins, lipids, and nucleotides. The course discusses the regulation of these metabolic pathways, either the anabolic or the catabolic one, and their integration in different conditions. The course illustrates the related energetics (i.e. calculations of energy gain or loss) to these metabolic pathways. Also, the course relates the derangement of these metabolic pathways of the different macronutrients to several acquired or genetic disorders